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VOLUME 10 , ISSUE 1 ( January-December, 2020 ) > List of Articles
Deepinder Chhina, Shikha Garg, Rajoo Chinna, Pulkit Dhiman, Divyani Gupta
Keywords : Coinfection, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus, Opportunistic infections
Citation Information : Chhina D, Garg S, Chinna R, Dhiman P, Gupta D. Study of Prevalence of Hepatitis B, Hepatitis C, and Other Opportunistic Coinfections in HIV-infected Patients in a Tertiary Care Hospital of North India. J Gastrointest Infect 2020; 10 (1):7-10.
License: CC BY-NC 4.0
Published Online: 29-12-2020
Copyright Statement: Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.
Background and objectives: There is only limited information on the prevalence of coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV)-infected individuals, resulting in greater morbidity and mortality. This study was done to evaluate the prevalence of HBV and HCV in HIV-infected individuals attending a tertiary care hospital in north India. Materials and methods: A total of 104 HIV patients were included in this study of 6-month duration (January–June 2019). Samples were tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies by rapid detection method and/or enzyme-linked immunosorbent assay (ELISA). HBsAg positive serum samples and anti-HCV positive samples were further tested for HBV-DNA and HCV-RNA, respectively. Other opportunistic infections were studied along with it. Results: Among the 104 HIV-positive patients, 11 (10.6%) were anti-HCV positive and 7 of 11 (63.6%) were positive for HCV-RNA. Three (2.8%) suffered from chronic HBV coinfection (HBsAg positive) and 2 of 3 (66.7%) were positive for HBV-DNA. Triple infection with HBV, HCV, and HIV was seen in 0.9% of patients. The most common mode of transmission was sexual promiscuity (76%), followed by infected needle/unknown (13.5%), and a history of intravenous drug abuse (10.5%). The demographic distribution shows the maximum number of patients (38.5%) belonging to the Ludhiana district of Punjab. Interpretation and conclusions: The findings show a prevalence of 10.6 and 2.8% for HCV and HBV, respectively, in HIV-positive patients. Coinfection with HCV-HIV is more frequent than HBV-HIV. Hence, all HIV patients need to be routinely tested for markers of HBV and HCV.
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