Journal of Gastrointestinal Infections

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VOLUME 8 , ISSUE 1 ( December, 2018 ) > List of Articles

ORIGINAL ARTICLE

Etiological Profile of Cirrhosis in a Tertiary Care Institute in Northern India

Deepinder Kaur, Rajoo S Chhina, Omesh Goyal, Prerna Goyal

Keywords : Cirrhosis, Hepatitis, Prevalence

Citation Information : Kaur D, Chhina RS, Goyal O, Goyal P. Etiological Profile of Cirrhosis in a Tertiary Care Institute in Northern India. J Gastrointest Infect 2018; 8 (1):28-31.

DOI: 10.5005/jp-journals-10068-0017

License: CC BY-NC 4.0

Published Online: 00-12-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Cirrhosis of the liver is associated with increased morbidity and mortality. There is paucity of data on the etiological profile of cirrhosis in Punjab. The purpose of this study was to evaluate the etiological profile of liver cirrhosis in adults in a tertiary care institute in northern India. Materials and methods: This study included all adult patients with cirrhosis admitted to the Gastroenterology unit of a tertiary care institute in northern India from January 2013 to December 2016. The diagnosis of cirrhosis was made based on the clinical, radiological, biochemical, and/or histological criteria. Patients with incomplete etiological workup were excluded. Results: A total of 716 hospitalized patients with cirrhosis were included. The mean age of patients was 54 ± 9.3 years (18–82 years), and male:female ratio was 5.7:1. Most common etiologies of cirrhosis were: alcohol (49.2%; n = 352), hepatitis C virus (HCV) infection (29.4%; 211), and nonalcoholic fatty liver disease (NAFLD) (13.6%; 98). Hepatitis B virus (HBV) infection was identified in 3.9% (n = 28) patients only. Other uncommon causes of cirrhosis were: autoimmune (n = 8; 1.1%), Wilson’s disease (n = 5; 0.7%), celiac disease (n = 3; 0.4%), Budd–Chiari syndrome (BCS) (n = 1; 0.1%), and cryptogenic (n = 10; 1.4%). Conclusion: In this study, alcohol and HCV infection were the most common causes of cirrhosis. Preventive measures are urgently required to control these factors to decrease morbidity and mortality.


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