Journal of Gastrointestinal Infections

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VOLUME 7 , ISSUE 1 ( 2017 ) > List of Articles

ORIGINAL ARTICLE

Gastrointestinal Manifestations of Scrub Typhus in Children and Adults from Puducherry and Neighboring Tamil Nadu State, India

Velmurugan Anitharaj, Dhandapany Gunasekaran, Jothimani Pradeep, Selvaraj Stephen

Keywords : Gastrointestinal symptoms, Orientia tsutsugamushi, Scrub typhus, Scrub typhus immunoglobulin M enzyme-linked immunosorbent assay.

Citation Information : Anitharaj V, Gunasekaran D, Pradeep J, Stephen S. Gastrointestinal Manifestations of Scrub Typhus in Children and Adults from Puducherry and Neighboring Tamil Nadu State, India. J Gastrointest Infect 2017; 7 (1):1-4.

DOI: 10.5005/jogi-7-1-1

License: CC BY-SA 4.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2017 Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Scrub typhus (ST) is reported from almost every Indian state. In our tertiary care teaching hospital at Puducherry, we looked for gastrointestinal (GI) manifestations of ST in children as well as adults and correlated with laboratory findings. We examined 588 serum samples for immunoglobulin M (IgM) antibody against Orientia tsutsugamushi by enzyme-linked immunosorbent assay (ELISA) and observed that 335 (56.97%) of these clinically suspected ST patients were positive, comprising 134 children and 201 adults. Statistically significant (p ≤ 0.05) number of adults had nausea (p = 0.000) and abdominal pain (p = 0.020) than children. Similar trend was observed in adults with reference to increased liver enzymes (aspartate aminotransferase/ alanine aminotransferase/alkaline phosphatase; p = 0.000), creatinine (>1.0 mg/dL; p = 0.007), and platelet count (≤1.5 lakhs/mm3; p = 0.026). Rash in children is the only statistically significant manifestation than adults (p = 0.03). More number of children were positive than adults, but without any statistical significance, with reference to other parameters like cough/expectoration (p = 0.735), hepatomegaly (p = 0.730), and eschar (p = 0.721).


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