Journal of Gastrointestinal Infections

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VOLUME 3 , ISSUE 1 ( 2013 ) > List of Articles

ORIGINAL ARTICLE

Profile and outcome of liver diseases in pregnancy -Ahospital based study

Deepinder Kaur, Rajoo Singh Chhina, Ashima Kaura, Vishal *, H. S. Pannu, Amandee *

Keywords : Hepatitis, Liver disease, Maternal mortality

Citation Information : Kaur D, Chhina RS, Kaura A, * V, Pannu HS, * A. Profile and outcome of liver diseases in pregnancy -Ahospital based study. J Gastrointest Infect 2013; 3 (1):41-44.

DOI: 10.5005/jogi-3-1-41

License: CC BY-SA 4.0

Published Online: 01-07-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background & Objective: Liver disease in pregnancy can have serious consequences. We studied the profile of liver disease in pregnant women and its correlation with outcome of pregnancy during the hospital stay in a tertiary care hospital. Methods: Pregnantwomen with liver disease admitted in the departments of Medicine, Gastroenterology and Obstetrics & Gynaecology between January 2011 and June 2012 in a tertiary care hospital of North India were evaluated for various parameters. Results: Out of 2663 pregnant women, 92 patients (3.45%) were diagnosed to have liver disease. Acute viral hepatitis (AVH) was found in 42 (45.6%) and pregnancy specific liver disease in 39 (42.4%) patients. Hypertensive disorder of pregnancy including HELLP Syndrome (Hemolysis, Elevated liver enzymes, Low platelet count) was seen in 27 patients (29.3%). Four patients had leptospirosis and hepatitis E co-infection. Overallmaternal and perinatal mortality was 7.6% (7/92) and 25% (23/92) respectively. Interpretation and Conclusion: Acute viral hepatitis (45.6%) was the most common cause of liver disease in pregnancy in our study.


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  1. Sookoian S. Liver disease during pregnancy: acute viral hepatitis. Ann Hepatol 2006;5(3):231-6.
  2. Jayanthi V, Udayakumar N. Acute liver failure in pregnancy: an overview. Minerva Gastroenterol Dietol 2008:54(1):75-84.
  3. Devarbhavi H, Kremers WK, Dierkhising R, Padamanabhan L. Pregnancy-associated acute liver disease and acute viral hepatitis: differentiation, course and outcome. J Hepatol 2008;49(6): 930-5.
  4. Navaneethan U, Al Muhajer M, Shata MT. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int 2008;28(9):1190-9.
  5. Ch’ng CL, Morgan M, Hainsworth I, Kingham JG, Prospective study of liver dysfunction in pregnancy in Southwest Wales. Gut 2002;51(6):876-80.
  6. Harish K, Nitha R, Harikumar R, Sunil Kumar K, Varghese T, Sreedevi NS, et al. Prospective evaluation of abnormal liver function test in pregnancy. Trop Gastroentrol 2005;26(5):188- 93.
  7. Jaiswal SP, Jain AK, Naik G, Soni N, Chitnis DS. Viral hepatitis during pregnancy. Int J Gynaecol Obstet 2001;72(2):103-8.
  8. Nayak NC, Panda SK, Datta R, Zuckerman AJ, Guha DK, Madangopalan N, et al. Aetiology and outcome of acute viral hepatitis in pregnancy. J Gastroenterol Hepatol 1989;4(4):345- 52.
  9. Khuroo MS, Kamili S. Aetiology, clinical course and outcome of sporadic acute viral hepatitis in pregnancy. J Viral Hepat 2003;10(1):61-9.
  10. Tsega E, Krawczynski K, Hansson BG, Nordenfelt E. Hepatitis E virus infection in pregnancy in Ethiopia. Ethiop Med J 1993;31(3):173-81.
  11. Kuscu NK, Koyuncu F. Hyperemesis gravidarum: current concepts and management. Postgrad Med J 2002;78(916):76-9.
  12. Pal R, Aggarwal R, Naik SR, Das V, Naik S. Immunological alterations in pregnant women with acute hepatitis E. J Gastroenterol Hepatol 2005;20(7);1094-101.
  13. Tsega E, Hansson BG, Krawczynski K, Nordenfelt E. Acute sporadic viral hepatitis in Ethiopia: causes, risk factors, and effects on pregnancy. Clin Infect Dis 1992;14(4):961-5.
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