Journal of Gastrointestinal Infections

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VOLUME 3 , ISSUE 1 ( 2013 ) > List of Articles

REVIEW ARTICLE

Probiotics in neonatology: can it be adopted as a standard of care?

Deepinder Kaur, Rajoo Singh Chhina, Kamal Arora

Keywords : *

Citation Information : Kaur D, Chhina RS, Arora K. Probiotics in neonatology: can it be adopted as a standard of care?. J Gastrointest Infect 2013; 3 (1):12-18.

DOI: 10.5005/jogi-3-1-12

License: CC BY-SA 4.0

Published Online: 01-07-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Probiotics aremicro-organisms that confer health benefits to the host. There is a growing body of evidence documenting the immune-modulatory ability of probiotic bacteria. The need for probiotic formulations has been appreciated for the health benefits in “topping up your good bacteria” or indeed in an attempt to normalise the dysbiotic microbiota associated with immunopathology. This review will focus on the use of probiotics in clinical practice, particularly related to neonatal practice, including explanations of what they are and how they work. Evidence for the health benefits of consuming probiotic bacteria are examined in several clinical conditions. Lastlywe have tried to solve the debated question that “should probiotics be used as standard of care in neonatal practice?” Key Points 1. Probiotics are enterally administered live “good’micro-organisms that colonise the gastrointestinal tract tomodulate the functions of the innatemicrobial community and immune system. 2. Thismay result in significant health benefits; for example enteral probiotic supplementation significantly reduces both severe necrotising enterocolitis and all-causemortality in preterminfants. 3. There is a debate on routine enteral probiotic supplementation for all preterm infants. Others advise caution pending results fromlarge clinical trials designed to address issues regarding safety and efficacy in the smallest, most vulnerable newborn population. 4. Probioticsmay also reduce atopic eczema in high-risk infantswhen administered to themother during pregnancy and to the infant post-natally and improve feeding tolerance in neonates.


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