Hepatitis C virus (HCV) is a heterogeneous virus with multiple genotypes. It has a slowly progressive course with a fatal outcome. Chronic infection with HCV is a major cause of liver cancer. Diagnosing the disease early at an early stage is necessary so as to prevent its progression to chronicity. Screening for anti-HCV IgG antibody can be done by a number of immunoassays but at the same time it becomes difficult to differentiate between acute and chronic infection. To overcome this problem nucleic acid testing for detecting HCV ribonucleic acid (RNA) can be used as themainstay for diagnosing the infection.
Ono-Nita SK, Nita ME, Carrilho FJ. Hepatitis C – facts in numbers. Arq Gastroenterol 2006;43(2):71-2.
Hosseini-Moghaddam SM, Iran-Pour E, Rotstein C, Husain S, Lilly L, Renner E, et al. Hepatitis C core Ag and its clinical applicability: potential advantages and disadvantages for diagnosis and follow-up? Rev Med Virol 2012;22(3):156–65.
Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 1998; 282 (5386): 103–7.
Simmonds P. Viral heterogeneity of the hepatitis C virus. J Hepatol 1999; 31:54–60.
Farci P, Purcell RH. Clinical significance of hepatitis C virus genotypes and quasispecies. Semin Liver Dis 2000;20:103–26.
Forns X, Purcell RHand Bukh J. Quasispecies in viral persistence and pathogenesis of hepatitis C virus. Trends Microbiol 1999;7(10):402–10.
Simmonds P, Alberti A, Alter HJ, Bonino F, Bradley DW, Brechot C, et al. A proposed system for the nomenclature of Hepatitis C viral genotypes. Hepatology 1994;19(5):1321-4.
Kamili S, Drobeniuc J, Araujo AC, Hayden TM. Laboratory Diagnostics for Hepatitis C Virus Infection. Clin Infect Dis 2012;55(1):S43–8.
Flamm SL. Chronic hepatitis C virus infection. JAMA 2003;289(18):2413-7.
Su J, Brook RA, Kleinman NL, Corey-Lisle P. The impact of hepatitis C virus infection on work absence, productivity, and healthcare benefit costs. Hepatology 2010;52(2):436-42.
Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention. MMWR Recomm Rep 2003;52:1–13.
Das MR, Ali N, Aruna B, Rama D, Nambiar A, Rehana Z et al. Indian strains of hepatitis C: Prevalence and detection. Curr Sci 1993;65:477–83.
Panigrahi AK, Nanda SK, Dixit RK, Acharya SK, Zuckerman AJ, Panda SK. Diagnosis of hepatitis C virus-associated chronic liver disease in India: comparison of HCV antibody assay with a polymerase chain reaction for the 5' noncoding region. J Med Virol 1994;44:176–9.
Poduri CD, Khanna A, Sugunan VS, Das MR. A conserved motif at the end of hypervariable region (HVR 1) of hepatitis C virus: potential tool in diagnosis. Immunologist 1998;6(1):429.
Poduri CD, Khanna A, Khundmiri SJ, Khaja MN, Kumar KS, Sugunan VS, et al. Predominance of antibodies to hepatitis C virus envelope proteins in various disease statuses of hepatitis C. Acta Virol 2001;45(1):1–6.
Testing for HCVInfection: An Update of Guidance for Clinicians and Laboratorians. Centers for Disease Control and Prevention. Morb Mortal Wkly Rep 2013;62(18):362-5.
Suri P, Chhina D, Gupta V, Singh J, Chopra P, Singh R, et al. Seroprevalence of parenterally and enterally transmitted hepatitis viruses in a tertiary care hospital of North India – A two year study. J of Gastro Infs 2012;2:46-51.
Panigrahi AK, Panda SK, Dixit RK, Rao KV, Acharya SK, Dasarathy S, et al. Magnitude of hepatitis C virus infection in India: prevalence in healthy blood donors, acute and chronic liver diseases. J Med Virol 1997;51(3):167-74.
Sharma R, Sinha P, Bachiwal R, Rishi S. Seroprevalence of Antihepatitis C Virus Antibody in a Hospital-based population of Jaipur, Rajasthan. Indian J Community Med 2007;32(2):158-9.
Mishra S, Chayani N, Sarangi G, Mallick B, Pati SB. Seroprevalence of anti HCV antibody in and around Cuttack, Orissa. Indian J Med Microbiol 2002;20(1):40-1.